Vinciane Rebours

The paper identifies distinct progression paths in pancreatic papillary cystic neoplasms using integrated transcriptomics and histology, enabling phenotype-specific prediction of high-grade dysplasia.

This study shows that loss of HNF1B contributes to IPMN initiation and identifies its role as a tumor suppressor in pancreatic ductal cells.

This study shows that VPS34-driven autophagy restricts cancer initiation by preventing transdifferentiation and reducing oncogenic KRAS promotion in pancreatic acinar cells.

The paper proposes a new variant classification framework for chronic pancreatitis, introducing new categories to better classify variants in disease-causing and predisposing genes.

The paper identifies p.Arg90Leu as a variant in CELA3B associated with chronic pancreatitis, reverting to an ancestral allele and confirming CELA3B's role in CP etiology.