Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period
Sarah Canetta, Emma S. Holt, Laura Benoit, Eric Teboul, Gabriella M Sahyoun, Robert Todd Ogden, Alexander Z. Harris, Christoph Kellendonk
The paper shows that inhibiting parvalbumin interneurons in the prefrontal cortex during juvenile and adolescent periods causes lasting impairments in adult circuit function and behavior, which can be reversed by reactivating these neurons in adulthood.
eLife · Dec 13, 2022Peer-reviewedNeuroscience