Christoph Kellendonk

Striatal acetylcholine enables latent-state creation during reversal learning

This study shows that striatal acetylcholine supports reversal learning by promoting state construction in reinforcement learning.

Altered striatal dopamine regulation in ADGRL3 knockout mice

This study examines how ADGRL3 knockout affects dopamine release in mice, finding increased ex vivo release and reduced in vivo task-induced signals in the nucleus accumbens.

A corticostriatal learning mechanism linking excess striatal dopamine and auditory hallucinations

This paper develops a computational model linking striatal dopamine levels to auditory hallucinations through corticostriatal plasticity and validates it with mouse and human data.

Prefrontal representations of retrospective spatial working memory in a rodent radial maze task

The paper investigates prefrontal cortex (PFC) neuronal activity during a complex spatial working memory task in rodents and finds retrospective mnemonic representations of spatial information during the delay phase, particularly on error trials.

Inhibition of striatal indirect pathway during second postnatal week leads to long lasting deficits in motivated behavior

This study shows that inhibiting the striatal indirect pathway during the second postnatal week in mice causes long-lasting deficits in motivated behavior and dopamine adaptation.

Adolescent Thalamocortical Inhibition Alters Prefrontal Excitation-Inhibition Balance.

This study inhibits thalamo-prefrontal projections in adolescent mice and finds altered synaptic connectivity and cognitive deficits in adulthood.

Dopaminergic D2 receptor modulation of striatal cholinergic interneurons governs sequence learning

This study shows that deleting D2 receptors from striatal cholinergic interneurons impairs action sequence learning, while viral replacement rescues this behavior.

Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period

The paper shows that inhibiting parvalbumin interneurons in the prefrontal cortex during juvenile and adolescent periods causes lasting impairments in adult circuit function and behavior, which can be reversed by reactivating these neurons in adulthood.

Dopamine D2Rs Coordinate Cue-Evoked Changes in Striatal Acetylcholine Levels

This study investigates the role of dopamine D2 receptors in coordinating acetylcholine and dopamine signals in the striatum during reward-related behaviors and finds that D2Rs regulate the timing and magnitude of acetylcholine dips.

Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning

This study shows that dopamine D2 receptors in cholinergic interneurons modulate the pause in neuronal activity and impair inhibitory learning in a Go/No-Go task.

Cortical Overgrowth in a Preclinical Forebrain Organoid Model of CNTNAP2-Associated Autism Spectrum Disorder

This study uses patient-derived forebrain organoids to investigate the effects of a CNTNAP2 mutation on cortical development, finding increased cell proliferation and differential gene expression associated with ASD.