NeurosciencebioRxivPreprint
Capturing the biology of disease severity in an organoid model of LIS1-lissencephaly
Lea Zillich, Matteo Gasparotto, Andrea Carlo Rossetti…·Julia Ladewig
This study uses LIS1-lissencephaly patient organoids to identify severity-dependent phenotypes and molecular mechanisms, and demonstrates that mTOR inhibitors can rescue disease-related changes.
3 citations