Annasara Artioli

Serotonergic innervation and cortical progenitor regulation in human brain assembloids

This study uses human brain assembloids to show serotonergic innervation influences cortical progenitor states and proliferation during development.

A defined 2D system for generating and expanding human basal radial glia from iPSCs

This study develops a 2D system to generate human basal radial glia from iPSCs, showing they exhibit key molecular and functional features of native cells.

A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder

This study characterizes molecular changes in the ventral striatum of individuals with cocaine use disorder using multi-omics and single-cell approaches, identifying perturbations in metabolic pathways and cell-type-specific alterations.

Two independent translocation modes drive neural stem cell dissemination into the human fetal cortex

The paper identifies two translocation modes for human fetal neural stem cells, showing that interphasic somal translocation (IST) accounts for 85% of their movement during cortical colonization.

Capturing the biology of disease severity in an organoid model of LIS1-lissencephaly

This study uses LIS1-lissencephaly patient organoids to identify severity-dependent phenotypes and molecular mechanisms, and demonstrates that mTOR inhibitors can rescue disease-related changes.