Author

Fabrizio Clarelli

Pennsylvania State UniversityORCID 0000-0002-3738-3469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Pia Abel zur WieschiD· 2 shared Alireza ShamsiD· 1 shared Antal MartinecziD· 1 shared Guro ForsdahliD· 1 shared H. Weiss· 1 shared Jessica M. ConwayiD· 1 shared Jingyi LiangiD· 1 shared Pierre AnkomahiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

Pia Abel zur WieschORCID

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2 papers

Recent·Most cited

A Mechanistic Approach to Optimize Combination Antibiotic Therapy

Fabrizio Clarelli, Pierre Ankomah, H. Weiss, Jessica M. Conway, Guro Forsdahl, Pia Abel zur Wiesch

This paper introduces a mechanistic model to optimize antibiotic combinations by incorporating drug mechanisms and testing synergy in Escherichia coli.

Biosystems · Dec 24, 2024Peer-reviewedPharmacology & Toxicology

vCOMBAT: a Novel Tool to Create and Visualize a COmputational Model of Bacterial Antibiotic Target-binding

Vi Ngoc-Nha Tran, Alireza Shams, Sinan Ascioglu, Antal Martinecz, Jingyi Liang, Fabrizio Clarelli, Rafal J. Mostowy, Ted Cohen, Pia Abel zur Wiesch

The paper introduces vCOMBAT, a web-based tool for creating and visualizing computational models of bacterial antibiotic target-binding using clinical drug concentration data.

BMC Bioinformatics · Jan 6, 2022Peer-reviewedBioinformatics