CD8+CD20+ Cytotoxic T Lymphocytes Exhibit Augmented Degranulation and Pro-inflammatory Potential in Multiple Sclerosis
Özgür Albayrak, Selen Ünlü, Nazan AKKAYA, Ali Burak Kızılırmak, Tansu Doran, Mina Üzülmez, Işıl Baytekin, Önder Kemal Soylu, Mesrure Köseoğlu, Burcu Yüksel, Aysun Soysal, Atay Vural
This study identifies CD8+CD20+ cytotoxic T lymphocytes in MS patients, showing increased degranulation and pro-inflammatory cytokine production, particularly Granzyme K, contributing to CNS inflammation.
bioRxiv · Feb 2, 2026 · PreprintImmunology