Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors
Damon May, Steven Woodhouse, Matthew T. Noakes, KATHRYN DOROSCHAK, Rebecca Elyanow, Amanda J. Moore, Edward J. Osborne, Brad Greenfield, Tim Hayes, Ruth T. Taniguchi, Zheng Yang, John Grino, Rachel Byron, Jamie Oaks, Haiyin Chen‐Harris, , Harlan S. Robins
The paper identifies immune exposure signatures by clustering T-cell receptors co-occurring across donors, linking them to specific pathogens and HLA alleles.
Frontiers in Immunology · Sep 18, 2026Peer-reviewedImmunology