Haiyin Chen‐Harris

The paper identifies immune exposure signatures by clustering T-cell receptors co-occurring across donors, linking them to specific pathogens and HLA alleles.

This study identifies HLA allele-specific biases in TCR Vβ usage, showing germline-encoded preferences shape TCR-HLA compatibility and influence TCR-pHLA specificity.

The paper identifies CeD-specific TCRs in peripheral blood that classify celiac disease independently of gluten intake, showing higher predictive power than traditional TCRs.

The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.

Seq2MAIT identifies MAIT cells from bulk TCR-sequencing data using a transformer-based model, achieving AUROC >0.80 across datasets.

The paper shows that polygenic risk scores for skin autoimmunity affect the response to immune checkpoint blockade in bladder cancer, with higher vitiligo and psoriasis scores linked to better outcomes.