Matthew T. Noakes

The paper identifies immune exposure signatures by clustering T-cell receptors co-occurring across donors, linking them to specific pathogens and HLA alleles.

IMMREP25 evaluates TCR:pMHC binding prediction for unseen peptides, showing improved performance with structural modeling but still below random guessing.

This study identifies HLA allele-specific biases in TCR Vβ usage, showing germline-encoded preferences shape TCR-HLA compatibility and influence TCR-pHLA specificity.