TRIB2 couples UCP1 degradation to thermogenic adaptation and metabolic health
Jiin-Horng Lee, Li-Yun Chueh, Sui-Chih Tien, Hsiao-Lin Lee, Kou-Ray Lin, Tung-Yuan Lee, Tony Pan-Hou Che, Jeffrey J.Y. Yen, Chun‐Mei Hu, Yi‐Cheng Chang
This study identifies a TRIB2 variant linked to thermogenic capacity and shows that TRIB2 promotes UCP1 degradation, affecting metabolic health and obesity resistance.
bioRxiv · Oct 26, 2025 · PreprintMolecular Biology