Yi‐Cheng Chang

This paper performs a local ancestry-aware GWAS on SCD cohorts to identify novel genetic loci associated with eGFR, uncovering regions linked to inflammation, ECM integrity, and other pathways relevant to SCD nephropathy.

The paper analyzes expression and splicing quantitative trait loci (e/sQTL) across multiple tissues in the TOPMed dataset and finds that secondary e/sQTL signals are still discoverable, with many GWAS signals colocalizing with these e/sQTL.

This study investigates the association between mosaic loss of Y chromosome (mLOY) and lung function, emphysema, and epigenetic aging in men across multiple cohorts.

This study identifies a TRIB2 variant linked to thermogenic capacity and shows that TRIB2 promotes UCP1 degradation, affecting metabolic health and obesity resistance.

This study investigates how hyperglycemia worsens gut barrier disruption and liver immune dysfunction after myocardial infarction, leading to increased microbial dissemination and systemic inflammation.

The paper identifies PTGR2 inhibitors as a new therapy for diabetes and obesity by improving glucose homeostasis and preventing diet-induced obesity without side effects.

This study analyzes mitochondrial DNA variation in the Taiwan Biobank, identifying pathogenic variants and associations with complex traits like myopia and renal function.

The paper validates novel telomere length regulation genes POP5 and KBTBD6 identified through trans-ancestry GWAS using functional experiments in blood cells.

This study identifies 12,111 SNPs associated with height from 5.4 million individuals, explaining most common SNP-based heritability and showing ancestry-specific prediction accuracy.

This study identifies 35 genes associated with circulating lipid levels using rare coding variants from 170,000 exomes across multiple ancestries.

The paper uses whole genome sequencing to identify genetic loci associated with platelet aggregation, including novel variants in RGS18, SVEP1, and PEAR1.