DNA repair functions are essential for bacterial stress defense but render antibiotic tolerant sub-populations susceptible to ciprofloxacin and gentamicin upon prolonged treatment
Yingkun Wan, Jiaqi Zheng, Heng Heng, Yang Tang, Lianwei Ye, Edward Wai‐Chi Chan, Sheng Chen
This study shows that bacterial tolerant subpopulations remain metabolically active and become susceptible to antibiotics targeting DNA and protein synthesis after prolonged stress.
bioRxiv · Feb 3, 2025 · PreprintMicrobiology