GenomicsbioRxivPreprint
Topologically associating domains can arise from stochastic folding of heterogeneous fluidlike chromatin
Luming Meng, Fu Kit Sheong, Qiong Luo
This study shows that stochastic folding of fluidlike chromatin with DNA-packing density heterogeneity can form TADs without cohesin-mediated extrusion, and predicts TAD dynamics during T cell differentiation.