Luming Meng

This study shows that stochastic folding of fluidlike chromatin with DNA-packing density heterogeneity can form TADs without cohesin-mediated extrusion, and predicts TAD dynamics during T cell differentiation.

The paper proposes that random folding of heterogeneous chromatin fibers underlies topologically associating domains (TADs) and shows that a model can predict chromatin reorganization during differentiation.

Si-C reconstructs biologically valid super-resolution 3D genome structures from sparse single-cell Hi-C data, revealing cell-to-cell variation and hyperfine chromatin features.

This paper identifies that immuno-positive neoantigens cluster in 3D genome regions and are enriched in active chromosomal compartments, suggesting 3D genome information can improve neoantigen prioritization.

The paper develops a method to model high-resolution 3D chromatin structures from single-cell Hi-C data, revealing that protein-marked loci aggregate coherently to regulate gene activation across cells.