Ethan J. Greenblatt

This study shows that declining ribosome function contributes to oocyte aging by reducing translational capacity and causing developmental defects.

The paper shows FMRP protects long mRNAs from repression by Me31B/DDX6, challenging the view of FMRP as a translational repressor.

This study shows FMRP activates translation of large proteins and promotes Poe/UBR4 production in RNP particles, which regulate cell growth and MAPK signaling in the nervous system.

This study shows prolonged storage of Drosophila oocytes leads to meiotic spindle instability, similar to human oocyte issues, and identifies Hsp26 and Hsp27 as key factors in age-related decline.

The paper identifies FMR1 as a translational activator of large proteins in Drosophila oocytes and neurons, linking its function to neural defects and ovarian failure.