Author

Matilde Rodrigues da Fonseca

Science for Life LaboratoryORCID 0000-0002-3809-7632Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Bennie B. L. G. LemmensiD· 2 shared Bruno UriéniD· 2 shared Giovanni GiglioiD· 2 shared Ana AgostinhoiD· 1 shared Carmen NavarroiD· 1 shared Gemma Quijada· 1 shared Hans BlomiD· 1 shared Jiří BártekiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Bennie B. L. G. LemmensORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 23, 2026

✦ In-depth digest

2C-RT Quantifies Genome-Wide DNA Replication Perturbations and Redefines RIF1-CDC7 Regulation of Replication Timing

Bruno Urién, Philip Yuk Kuwong, Giovanni Giglio…·Bennie B. L. G. Lemmens

Sorting S-phase cells by Cyclin A2 rather than DNA content exposes a uniform genome-wide delay after CDC7 inhibition and a broad replication timing advance in RIF1 knockout.

DOI 10.64898/2026.10.09.758048

humanimaging

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Cell BiologyThe EMBO JournalPeer-reviewedOct 7, 2025

Spatial mapping of DNA synthesis reveals dynamics and geometry of human replication nanostructures

Michael Hawgood, Bruno Urién, Ana Agostinho…·Bennie B. L. G. Lemmens

This study introduces 3D-SPARK, a method to visualize and quantify DNA replication dynamics at the nanoscale in 3D human cells, showing changes in replication structures under different conditions.

1 citation

humanDNA methylation

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