Jiří Bártek

This study introduces 3D-SPARK, a method to visualize and quantify DNA replication dynamics at the nanoscale in 3D human cells, showing changes in replication structures under different conditions.

This study identifies UBA1 mis-splicing as a therapeutic target in SF3B1-mutant myelodysplastic syndromes, showing that UBA1 inhibition sensitizes these cells to treatment.

This study identifies SLC7A11 as a mediator of cisplatin resistance in cancer cells and shows asparaginase therapy can target this resistance.

The paper shows RNA polymerase II is essential for repairing rDNA breaks in nucleolar caps, preventing genomic instability and cancer cell death.

The paper shows that nascent RNA generated by RNA polymerase II near DNA breaks influences the choice of DNA repair pathway, favoring homologous recombination over non-homologous end joining.

The paper identifies p97 ATPase as a key player in removing trapped PARP1 from chromatin, enhancing PARPi-induced cytotoxicity in homologous recombination-defective cells.

This study identifies SPHK inhibitors as a new class of translation suppressors independent of mTOR, linking lipid metabolism to mRNA translation.

The paper uses deep learning and association rule mining to predict drug response in cancer cell lines, outperforming existing methods and demonstrating a novel approach for therapeutic target identification.