PhysiologyeLifePeer-reviewed
Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging
Duilio Michele Potenza, Xin Cheng, Guillaume Ajalbert…·Xiu‐Fen Ming
This study identifies non-cell-autonomous and cell-autonomous roles of arginase-II in cardiac aging, showing its impact on inflammation, fibrosis, and ischemic injury through macrophage-derived IL-1β and fibroblast mtROS.