Andrea Brenna

This study shows that Cdk5 activity, modulated by light, gates rapid circadian phase shifts by regulating calcium influx and signaling pathways in SCN neurons.

This study shows CDK5 regulates peripheral circadian clocks by affecting their period, gene expression amplitude, and phase in mouse cells.

The paper shows light affects mood-related behaviors in mice by inducing the clock gene Per1 in the lateral habenula, altering gene expression in the mesolimbic dopaminergic system.

This study identifies CDK5 as a kinase that regulates the mammalian circadian clock by phosphorylating PER2, facilitating its nuclear entry and maintaining circadian period.