Metastatic site influences driver gene function in pancreatic cancer
Kaloyan M. Tsanov, Francisco M. Barriga, Yu-Jui Ho, Direna Alonso‐Curbelo, Geulah Livshits, Sha Tian, Richard P. Koche, Timour Baslan, Janelle M. Simon, Alexandra N. Wuest, José Santos Reyes, Jin Myung Park, Wei Luan, John Erby Wilkinson, Umesh Kumar Bhanot, , Scott W. Lowe
This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.
Nature Cancer · Sep 25, 2025Peer-reviewedCancer Biology