Author

Janelle M. Simon

Memorial Sloan Kettering Cancer CenterORCID 0009-0004-8259-5016Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Scott W. LoweiD· 2 shared Wei LuaniD· 2 shared Yu-Jui HoiD· 2 shared Alexandra N. WuestiD· 1 shared Almudena Chaves PereziD· 1 shared Ana Marie PereaiD· 1 shared Aveline A. FillioliD· 1 shared Charles M. RudiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Scott W. LoweORCID

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2 papers

Recent·Most cited

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

Clemens Hinterleitner, Valentin J.A. Barthet, Hailey V. Goldberg, Kristen C. Vogt, Ana Marie Perea, Logan R. Hillger, Stephen B. Ruiz, Domhnall McHugh, Yu-Jui Ho, Almudena Chaves Perez, Maria Skamagki, Sara Flowers, Hannah C. Styers, Natasha Rekhtman, Xueqian Zhuang, , Scott W. Lowe

P-selectin-targeted fucoidan nanoparticles carrying Navitoclax or dBET6 deplete a senescent-like, lipid-associated macrophage subset, reverse mouse liver and lung fibrosis with less toxicity, and restore checkpoint therapy response in fibrotic tumors.

Science · Sep 24, 2026Peer-reviewedCancer Biology✦ In-depth digest

Metastatic site influences driver gene function in pancreatic cancer

Kaloyan M. Tsanov, Francisco M. Barriga, Yu-Jui Ho, Direna Alonso‐Curbelo, Geulah Livshits, Sha Tian, Richard P. Koche, Timour Baslan, Janelle M. Simon, Alexandra N. Wuest, José Santos Reyes, Jin Myung Park, Wei Luan, John Erby Wilkinson, Umesh Kumar Bhanot, , Scott W. Lowe

This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.

Nature Cancer · Sep 25, 2025Peer-reviewedCancer Biology