John Erby Wilkinson

This study demonstrates that exon-skipping antisense oligonucleotides targeting H3.3K27M-altered DMG reduce proliferation and extend survival in a mouse model.

This study evaluates MALAT1-targeting ASOs in breast cancer using patient-derived organoid models, showing MALAT1's role in alternative splicing, metastasis, and tumor-stroma interactions.

This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.

This study shows that unresolved urinary tract infection leads to mammary tissue changes via collagen deposition and TIMP1, mediated by systemic host response.

This study identifies Platr4 as an ESC-specific lncRNA that regulates meso/endoderm lineage commitment by interacting with Tead4 to control Ctgf expression, leading to cardiac defects in knockout mice.

The paper shows pregnancy-induced changes in mammary epithelial cells lead to NKT cell expansion and promote mammary oncogenesis through CD1d expression.

The paper investigates how pregnancy alters the enhancer landscape of mammary epithelial cells and affects their response to cMYC-driven oncogenesis, finding that post-pregnancy cells are resistant to cMYC-induced proliferation.