Early Epigenetic and Metabolic Responses to the Adipocyte Secretome Reveal Stress-Adaptive States in Triple-Negative Breast Cancer
Ashley Townsel, Maya Jaffe, Shiyu He, Yifei Wu, Asia N. Ingram, Madison Tipton, Melissa Lambeth Kemp, Curtis James Henry, Karmella Ann Haynes
This study identifies how adipocyte secretome induces metabolic and epigenetic changes in TNBC cells, promoting stress-adaptive states through chromatin remodeling and metabolic reprogramming.
bioRxiv · Apr 8, 2026 · PreprintCancer Biology