Author

Maya Jaffe

Emory UniversityORCID 0000-0002-5610-0399Unclaimed ORCID profile · follow to get notified of new preprints

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Maya Jaffe1 paper

Biology Disciplines

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Synthetic Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Karmella Ann HaynesiD· 3 shared Ashley TownseliD· 2 shared Cara E. ShieldsiD· 2 shared Yifei WuiD· 2 shared Asia N. IngramiD· 1 shared Curtis James HenryiD· 1 shared Lauren HongiD· 1 shared Madison TiptoniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersSynthetic Biology

Karmella Ann HaynesORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 8, 2026

Early Epigenetic and Metabolic Responses to the Adipocyte Secretome Reveal Stress-Adaptive States in Triple-Negative Breast Cancer

Ashley Townsel, Maya Jaffe, Shiyu He…·Karmella Ann Haynes

This study identifies how adipocyte secretome induces metabolic and epigenetic changes in TNBC cells, promoting stress-adaptive states through chromatin remodeling and metabolic reprogramming.

DOI 10.64898/2026.04.06.716548

humanbulk RNA-seq

𝕏 PostBluesky

Synthetic BiologyACS Synthetic BiologyPeer-reviewedJul 8, 2025

Tet Transgene Activation is Disrupted in Lipogenic Triple Negative Breast Cancer Cells

Ashley Townsel, Yifei Wu, Maya Jaffe…·Karmella Ann Haynes

The paper shows that lipogenic metabolism in breast cancer cells disrupts Tet transgene activation by affecting chromatin remodeling substrates and cofactors.

3 citations

humanbulk RNA-seq

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Synthetic BiologybioRxivPreprintJan 23, 2023

PIC recruitment by synthetic reader-actuators to polycomb-silenced genes blocks triple-negative breast cancer invasion

Natecia L. Williams, Lauren Hong, Maya Jaffe…·Karmella Ann Haynes

The paper develops a synthetic reader-actuator to activate silenced tumor suppressor genes in triple-negative breast cancer cells, reducing invasion and promoting apoptosis.

DOI 10.1101/2023.01.23.525196

humanbulk RNA-seq

𝕏 PostBluesky