Shuguang Zhang

Structural bioinformatics of three Epstein-Barr Virus (EBV) Integral Membrane Proteins and their water-soluble QTY analogs

The paper designs water-soluble analogs of EBV membrane proteins using QTY residues, showing minimal structural changes and reduced hydrophobicity.

Structural Bioinformatics of Four Human Aquaporins and Their Water-Soluble QTY Analogs

The paper applies the QTY code with AlphaFold 3 to design water-soluble analogs of four human aquaporins while preserving their structure and function.

Structure Bioinformatics of Eight Human ATP Synthase Fo Subunits and Their AlphaFold3-Predicted Water-Soluble QTY Analogs

This paper applies the QTY code to eight human ATP synthase Fo subunits to reduce hydrophobicity while preserving structure, showing reduced hydrophobic patches and similar overall folds.

Towards robust machine olfaction: debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles

This paper develops a machine learning approach to analyze GC-MS urine data for prostate cancer detection, achieving performance comparable to medical detection dogs.

PSS: An enabling QTY server for designing water-soluble α-helical transmembrane proteins

The paper introduces a web server for QTY-based design of water-soluble α-helical transmembrane proteins and provides protocols for its use.