Exposure of negative-sense viral RNA in the cytoplasm initiates innate immunity to West Nile virus
Emmanuelle Genoyer, Jonathan Wilson, Joshua M. Ames, Caleb Stokes, Dante Moreno, Noa Etzyon, Andrew Oberst, Michael Gale
The paper identifies that exposure of single-stranded negative-sense viral RNA outside replication compartments during flavivirus infection triggers innate immunity via RIG-I interaction.
Molecular Cell · Jun 8, 2024Peer-reviewedMicrobiology