Michael Gale

The paper uses fibroblasts from 86 mammalian species to study virus-host susceptibility and innate immune responses across diverse mammals.

This study examines SIV dissemination in rhesus macaques after rectal infection, showing systemic infection occurs without local viral amplification at the entry site.

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

This study investigates ZIKV infection in fetal brain tissue, identifying astrocyte immune responses and neuronal dysfunction linked to congenital Zika syndrome.

This study investigates how SIV-induced immunosuppression affects ZIKV replication and persistence in pigtail macaques, finding increased viral persistence and chronic immune activation in the gastrointestinal tract.

The paper identifies a gut microbial signature predictive of RhCMV/SIV vaccine efficacy in rhesus macaques using 16S rRNA analysis and compositional data techniques.

The paper identifies that exposure of single-stranded negative-sense viral RNA outside replication compartments during flavivirus infection triggers innate immunity via RIG-I interaction.

scPathoQuant efficiently aligns and quantifies pathogen and host reads from scRNA-seq data in a single step, enabling analysis of viral and host sequence abundance in infected cells.

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

The paper develops CCFEA, a tool to analyze gene expression in Collaborative Cross founder strains infected with SARS-CoV or influenza A virus, linking genetic variation to infection and disease phenotypes.

The paper identifies an IL-15 response signature in vaccinated rhesus macaques that correlates with protection against SIV challenge following RhCMV/SIV vaccination.