Fanlei Hu

This study shows that a TREM2 agonist antibody rebuilds the synovial macrophage lining barrier in RA by shifting macrophage states toward a barrier-like phenotype.

This paper introduces an enrichment-free method to analyze native O-glycoproteomes, revealing high O-glycosylation in antibodies from autoimmune diseases.

This study identifies HLA-DQA1 as the major independent genetic risk for ACPA-positive RA in Han population through MHC region sequencing and HLA-typing.