Tao Zhang

Integrated optimization of experimental and computational workflows improves genome recovery in long-read gut metagenomics

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal-fetal interface

The paper uses single-cell transcriptomics to analyze cellular and molecular differences across maternal-fetal sections of the placenta, identifying key cell types and regulatory factors involved in placental development and preeclampsia.

iGWAS: image-based genome-wide association of self-supervised deep phenotyping of human medical images

The paper introduces iGWAS, a method using self-supervised deep learning to extract phenotypes from medical images for GWAS, finding new genetic loci related to retinal vessel development.

Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

This study uses Mendelian randomization to identify causal relationships between gut microbiome composition and blood metabolites in a Chinese cohort.

Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome

This study identifies genetic loci associated with the oral microbiome using metagenome-genome-wide association studies in over 1,915 individuals.

M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases

This paper performs M-GWAS on a Chinese cohort to identify genetic contributions to the gut microbiome and its associations with complex diseases.

Initial Whole Genome Sequencing and Analysis of the Host Genetic Contribution to COVID-19 Severity and Susceptibility

This study analyzes whole-genome sequencing data from 332 Chinese COVID-19 patients to identify genetic variants associated with disease severity and susceptibility.

Sequencing of the MHC region defines HLA-DQA1 as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population

This study identifies HLA-DQA1 as the major independent genetic risk for ACPA-positive RA in Han population through MHC region sequencing and HLA-typing.