Author

Huihui Yuan

Capital Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Christopher John CorriganiD· 1 shared Fanlei HuiD· 1 shared Hao YaniD· 1 shared Hongyun ZhaoiD· 1 shared Huanyu LongiD· 1 shared Jie Liu· 1 shared Jingyun Wang· 1 shared Kaixin LiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Christopher John CorriganORCID

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2 papers

Recent·Most cited

IgG4⁺ plasma cell enrichment and {lambda}-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary disease

Luo Duan, Hongyun Zhao, Yanqi Xia, Xiaoxia Ren, Huanyu Long, Lun Li, Mi Mu, Kaixin Li, Jie Liu, Yunpeng Dou, Ye Cui, Yan Chen, Zhe Lv, Christopher John Corrigan, Sebastian Lennox Johnston, , Ying Sun

This study identifies IgG4⁺ plasma cell enrichment and λ-chain-biased BCR remodeling in COPD, linking them to low-grade autoimmunity and chronic inflammation.

bioRxiv · Jun 30, 2026 · PreprintImmunology

TREM2 agonist antibody rebuilds the resident synovial macrophage lining barrier in rheumatoid arthritis

Huihui Yuan, Jingyun Wang, Qichao Wang, Le Jiang, Leixin Liu, Weicheng Shen, Peixia Li, Wanting Liu, Ziyu Liu, Fanlei Hu, Xu Cai, Wanli Liu, Qiong Wu, Xiumei Wang, Hao Yan, Xiaodan Sun

This study shows that a TREM2 agonist antibody rebuilds the synovial macrophage lining barrier in RA by shifting macrophage states toward a barrier-like phenotype.

bioRxiv · Feb 5, 2026 · PreprintBioengineering