GeneticsCirculation Genomic and Precision MedicinePeer-reviewed
Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates
Ellie Paige, Marc Clément, Fabien Lareyre…·Ziad Mallat
The paper investigates the effect of the IL6R-Asp358Ala variant on AAA growth and evaluates IL-6 pathway blockade in mouse models, finding no significant growth rate reduction but improved survival with trans-signalling inhibition.
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