Author

Fabien Lareyre

InsermORCID 0000-0002-6765-8021Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Marc ClémentiD· 2 shared Ziad MallatiD· 2 shared Adam S. ButterworthiD· 1 shared Alison J. FiniganiD· 1 shared Benjamin B. SuniD· 1 shared Céline GrenieriD· 1 shared D Julian A. Scott· 1 shared Daniel F. Freitag· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersPathology

Marc ClémentORCID

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2 papers

Recent·Most cited

PathologybioRxivPreprintOct 21, 2026

Modelling the human IL6RA Asp358Ala variant in mice: effects on atherosclerosis and abdominal aortic aneurysm

Minoru Takaoka, Rahul Sharma, Fabien Lareyre…·Ziad Mallat

This paper shows that introducing the IL6RA Glu357Ala substitution in mice reduces atherosclerosis and AAA, similar to the human IL6RA Asp358Ala variant's protective effect.

DOI 10.64898/2026.10.16.759391

mouseexperimental assay

𝕏 PostBluesky

GeneticsCirculation Genomic and Precision MedicinePeer-reviewedFeb 1, 2019

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

Ellie Paige, Marc Clément, Fabien Lareyre…·Ziad Mallat

The paper investigates the effect of the IL6R-Asp358Ala variant on AAA growth and evaluates IL-6 pathway blockade in mouse models, finding no significant growth rate reduction but improved survival with trans-signalling inhibition.

64 citationstop 2%

mousestatistical model

𝕏 PostBluesky