Author

Marc Clément

InsermORCID 0000-0002-6479-8360Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Ziad MallatiD· 3 shared Fabien LareyreiD· 2 shared Adam S. ButterworthiD· 1 shared Alan DaughertyiD· 1 shared Albert Phillip OwensiD· 1 shared Alison J. FiniganiD· 1 shared Anthony R. SpuzzilloiD· 1 shared Benjamin B. SuniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPathology

Ziad MallatORCID

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3 papers

Recent·Most cited

Modelling the human IL6RA Asp358Ala variant in mice: effects on atherosclerosis and abdominal aortic aneurysm

Minoru Takaoka, Rahul Sharma, Fabien Lareyre, Marc Clément, James Harrison, Leanne Masters, Yuning Lu, Dirk Paul, Ziad Mallat

This paper shows that introducing the IL6RA Glu357Ala substitution in mice reduces atherosclerosis and AAA, similar to the human IL6RA Asp358Ala variant's protective effect.

bioRxiv · Oct 21, 2026 · PreprintPathology

Platelets are Protective in Early Abdominal Aortic Aneurysm Formation

Hannah Russell, Anthony R. Spuzzillo, Tyler W. Benson, James Jaworski, Marc Clément, Yacine Boulaftali, Keith Louis Saum, Kelsey A. Conrad, Deborah A. Howatt, James P. Luyendyk, Scott J. Cameron, Bernhard Nieswandt, Steven R. Steinhubl, Alan Daugherty, Wolfgang Bergmeier, , Albert Phillip Owens

This study shows that platelet inhibition increases rupture risk in early abdominal aortic aneurysm models in mice.

bioRxiv · Oct 29, 2024 · PreprintPathology

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

Ellie Paige, Marc Clément, Fabien Lareyre, Michael J. Sweeting, Juliette Raffort, Céline Grenier, Alison J. Finigan, James E. Harrison, James E. Peters, Benjamin B. Sun, Adam S. Butterworth, Seamus C. Harrison, Matthew J. Bown, Jes Sanddal Lindholt, Stephen A. Badger, , Ziad Mallat

The paper investigates the effect of the IL6R-Asp358Ala variant on AAA growth and evaluates IL-6 pathway blockade in mouse models, finding no significant growth rate reduction but improved survival with trans-signalling inhibition.

Circulation Genomic and Precision Medicine · Feb 1, 2019Peer-reviewedGenetics