Author

Lixiang Zhai

Hong Kong Baptist UniversityORCID 0000-0002-3907-5910Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Assay:metagenomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Zhaoxiang BianiD· 2 shared Aiping LüiD· 1 shared Andrei L. OstermaniD· 1 shared Baisen CheniD· 1 shared Chao YangiD· 1 shared Chen Sun· 1 shared Chengrui WangiD· 1 shared Chi Chun WongiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Zhaoxiang BianORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer

Jiayan Wu, Yingyao Lai, Jinming Li, Lixiang Zhai, Pallavi Asthana, Lexin Chen, Minting Chen, Baisen Chen, Susma Gurung, Jin Lyu, Yijing Zhang, Lin Tao Lü, Shuojie Huang, Weihong Kuang, Hui Shi, , Hoi Leong Xavier Wong

This paper identifies 4-C-3 as an antitumor metabolite derived from cholesterol by gut microbiota, showing its efficacy in CRC models through dual inhibition of EGFR and KRAS.

bioRxiv · May 2, 2025 · PreprintCancer Biology

Exploring Population Differences in the Human Gut Microbiome: from Microbial Abundance to Single Nucleotide Polymorphisms

Jingjing Wang, Zhenmiao Zhang, Yang Chen, Xijie Zhou, Jiaxin Xiang, Chao Yang, Dmitry A. Rodionov, Andrei L. Osterman, Qinwei Qiu, Yusheng Deng, Yanmin Liu, Chengrui Wang, Xiaoxiao Shang, Li Huang, Chen Sun, , Lu Zhang

This study compares gut microbiome differences between Han Chinese and non-Chinese populations, identifying population-specific genome clusters and SNPs linked to functional traits.

bioRxiv · Apr 10, 2025 · PreprintMicrobiology