Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes
Takumi Kitamoto, Yun‐Kyoung Lee, Nishat Sultana, Hitoshi Watanabe, Wendy M. McKimpson, Wen Juan Du, Jason Fan, Bryan Diaz, Hua V. Lin, Rudolph L. Leibel, Sandro Belvedere, Domenico Accili
The paper shows that a small molecule FoxO1 inhibitor generates gut β-like cells, improving glucose tolerance in diabetes models.
Molecular Metabolism · Oct 28, 2022Peer-reviewedDevelopmental Biology