Takumi Kitamoto

The paper shows that a small molecule FoxO1 inhibitor generates gut β-like cells, improving glucose tolerance in diabetes models.

This paper investigates the transcriptional regulation of lipid and glucose metabolic genes in hepatic insulin resistance, finding distinct regulatory patterns and a model for their coexistence in type 2 diabetes.

This study identifies Cyb5r3 as a mediator of FoxO1-dependent mitochondrial dysfunction in beta-cells, leading to impaired insulin secretion and glucose intolerance.