Author

Ita Gruic‐Sovulj

University of ZagrebORCID 0000-0002-3930-8323Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:phylogenetics / evolution· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Liam M. LongoiD· 2 shared Alojzije BrkićiD· 1 shared Andre Lecona ButtelliiD· 1 shared Dan S. TawfikiD· 1 shared Igor ŽivkovićiD· 1 shared Jagoda JabłońskaiD· 1 shared Marc LeibundgutiD· 1 shared Nenad BaniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Liam M. LongoORCID

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2 papers

Recent·Most cited

C-terminal evolutionary remodelling of isoleucyl-tRNA synthetases is a prokaryote-specific strategy for tuning aminoacylation rate

Petra Modrusan, Alojzije Brkić, Andre Lecona Buttelli, Marc Leibundgut, Igor Živković, Nenad Ban, Liam M. Longo, Ita Gruic‐Sovulj

This study investigates the evolutionary remodelling of isoleucyl-tRNA synthetase C-terminal domains in prokaryotes, finding that such remodelling enhances aminoacylation rates.

bioRxiv · Feb 5, 2026 · PreprintBiochemistry

The evolutionary history of class I aminoacyl-tRNA synthetases indicates early statistical translation

Jagoda Jabłońska, Yao Chun-Chen, Liam M. Longo, Dan S. Tawfik, Ita Gruic‐Sovulj

This study reconstructs the evolutionary history of Class I aminoacyl-tRNA synthetases, finding that early AARSs were generalists capable of charging a wide range of amino acids, suggesting statistical translation evolved before specialized, accurate translation.

bioRxiv · Jun 9, 2022 · PreprintBioinformatics