Marc Leibundgut

C-terminal evolutionary remodelling of isoleucyl-tRNA synthetases is a prokaryote-specific strategy for tuning aminoacylation rate

This study investigates the evolutionary remodelling of isoleucyl-tRNA synthetase C-terminal domains in prokaryotes, finding that such remodelling enhances aminoacylation rates.

Molecular basis of the TRAP complex function in ER protein biogenesis

This study reveals the molecular architecture of the TRAP complex and its interactions with ribosomes and the translocon in ER protein biogenesis.

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

This study presents the cryo-EM structure of the mammalian ribosome during SARS-CoV-2 RNA translation, revealing the pseudoknot structure that facilitates ribosomal frameshifting and identifies a compound that inhibits viral replication.

SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation

This study shows SARS-CoV-2 Nsp1 binds to the 40S ribosomal subunit to inhibit translation by blocking mRNA entry, while viral mRNA enhances its own translation.

Structure and functional implications of WYL-domain-containing transcription factor PafBC involved in the mycobacterial DNA damage response

The paper determines the crystal structure of PafBC, a mycobacterial transcription factor with a WYL domain, and suggests RNA binding activates it through structural analysis and mutational screening.

Structure of the eukaryotic cytoplasmic pre-40S ribosomal subunit

The paper determines the structure of a cytoplasmic pre-40S ribosomal subunit using cryo-EM, revealing conformational changes and the roles of assembly factors in its maturation.