C-terminal evolutionary remodelling of isoleucyl-tRNA synthetases is a prokaryote-specific strategy for tuning aminoacylation rate
Petra Modrusan, Alojzije Brkić, Andre Lecona Buttelli, Marc Leibundgut, Igor Živković, Nenad Ban, Liam M. Longo, Ita Gruic‐Sovulj
This study investigates the evolutionary remodelling of isoleucyl-tRNA synthetase C-terminal domains in prokaryotes, finding that such remodelling enhances aminoacylation rates.
bioRxiv · Feb 5, 2026 · PreprintBiochemistry