Gretchen Long

This paper uses surprisal information-theoretic analysis on spatial transcriptomic data from human glioblastoma to uncover hidden spatial programs and interactions not detected by standard methods.

This paper develops a non-viral genome-editing method called STEP-RNPs that effectively treats Angelman syndrome in mice and human neurons, showing functional genetic rescue without off-target effects.

This study identifies two epigenetically-defined spatial niches in glioblastoma that influence cell state plasticity through local and long-range molecular signals.