Jiangbing Zhou

Decoding Spatial Programs in Human Glioblastoma Through Surprisal Information-Theoretical Analysis

This paper uses surprisal information-theoretic analysis on spatial transcriptomic data from human glioblastoma to uncover hidden spatial programs and interactions not detected by standard methods.

CAR-T-drug conjugate against solid tumor

This paper introduces CAR-T-drug conjugates (CAR-T-D-C) to improve CAR-T therapy for solid tumors by combining chemotherapy with CAR-T cells, enhancing tumor infiltration and immune response.

Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome

This paper develops a non-viral genome-editing method called STEP-RNPs that effectively treats Angelman syndrome in mice and human neurons, showing functional genetic rescue without off-target effects.

Spatial epigenomic niches underlie glioblastoma cell state plasticity

This study identifies two epigenetically-defined spatial niches in glioblastoma that influence cell state plasticity through local and long-range molecular signals.

VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes

This study shows that VEGF-C overexpression enhances brain fluid drainage, provides neuroprotection, and improves stroke outcomes in mice.