Marco Gallo

Ependymomas are cancers of the pre-neural crest/roof plate lineage

The paper identifies ependymomas as originating from the pre-neural crest/roof plate lineage using single-cell transcriptomics and lineage tracing.

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs

The paper shows that H3K27me3 spreading regulates chromatin architecture and gene repression, with implications for cell fate and tumor development.

Microbiome-derived hydroxyphenyl propanoates enhance antitumour immunity by potentiating gasdermin D activity in tumour-associated myeloid cells

This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.

EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism

This study investigates EZHIP mutations in pediatric brain tumors, showing their presence in new tumor types and revealing their role in neuronal-like gene programs and polyamine metabolism repression.

Spatial epigenomic niches underlie glioblastoma cell state plasticity

This study identifies two epigenetically-defined spatial niches in glioblastoma that influence cell state plasticity through local and long-range molecular signals.

Mutant IDH impairs chromatin binding by PDGFB to promote chromosome instability

This study shows that mutant IDH impairs PDGFB's chromatin binding, leading to chromosome instability and accelerated gliomagenesis.

Hi-C detects genomic structural variants in peripheral blood of pediatric leukemia patients

The paper demonstrates that Hi-C can detect structural variants, including translocations, in peripheral blood samples of pediatric B-ALL patients, offering a non-invasive alternative to bone marrow biopsies.

Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer

Copy-scAT deconvolutes single-cell chromatin accessibility to infer genetic subclones in cancer, revealing how genetics influence chromatin profiles and subclonal phenotypes.