Daniel D. Shaye

Chloride intracellular channel (CLIC) protein function in S1P-induced Rac1 activation requires membrane localization of the C-terminus, but not thiol-transferase nor ion channel activities.

This study identifies that the C-terminus of CLIC1 and CLIC4 is required for S1P-induced Rac1 activation, independent of their ion channel or thiol-transferase activities.

Syndecan Regulates Cellular Morphogenesis in Cooperation with the Netrin Guidance Pathway and Rho-family GTPases

This study shows that Syndecan, an HSPG, regulates the number of cellular projections in C. elegans excretory canal cells through interactions with Netrin guidance receptors and Rho-family GTPases.