CRAG: De novo characterization of cell-free DNA fragmentation hotspots in plasma whole-genome sequencing
Xionghui Zhou, Haizi Zheng, Hailu Fu, Kelsey Dillehay McKillip, Susan M. Pinney, Yaping Liu
The paper develops a method to identify cell-free DNA fragmentation hotspots in plasma whole-genome sequencing and shows their utility in detecting early-stage cancers with high specificity and sensitivity.
bioRxiv · Jul 16, 2020 · PreprintGenomics