The paper introduces the GA4GH Workflow Execution Service API, which standardizes workflow execution across different compute environments and demonstrates its cross-site functionality.

bioRxiv · Oct 24, 2026 · PreprintBioinformatics

Multifunctional RNA-binding proteins influence mRNA abundance and translational efficiency of distinct sets of target genes

Valentin Schneider-Lunitz, Jorge Ruiz‐Orera, Norbert Hübner, Sebastiaan van Heesch

The paper identifies 27 RBPs that regulate both mRNA abundance and translational efficiency in human hearts, with 21 affecting distinct sets of target genes through differential affinity for target length.

PLoS Computational Biology · Dec 8, 2021Peer-reviewedSystems Biology

Trans control of cardiac mRNA translation in a protein length-dependent fashion

Franziska Witte, Jorge Ruiz‐Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchı́s, Martin Vingron, , Sebastiaan van Heesch

The paper identifies a trans locus in rats that causes a protein length-dependent shift in translational efficiency, affecting cardiac hypertrophy and sarcomere protein stoichiometry.

Genome biology · Jun 28, 2021Peer-reviewedGenetics

A functional screen of translated pancreatic lncRNAs identifies a microprotein-independent role for LINC00261 in endocrine cell differentiation

Bjoern Gaertner, Sebastiaan van Heesch, Valentin Schneider-Lunitz, Jana Felicitas Schulz, Franziska Witte, Susanne Blachut, Steven M. Nguyen, Regina Men Men Wong, Ileana Matta, Norbert Hübner, Maike Sander

The paper identifies a microprotein-independent role for LINC00261 in endocrine cell differentiation during human pancreas development through genetic ablation of lncRNAs.

eLife · Aug 3, 2020Peer-reviewedDevelopmental Biology