Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes
Gaowei Wang, Joshua Chiou, Chun Zeng, Michael Miller, Ileana Matta, Jee Yun Han, Nikita Kadakia, Mei-Lin Okino, Elisha Beebe, Medhavi Mallick, Joan Camuñas-Soler, Theodore dos Santos, Xiao-Qing Dai, Cara E. Ellis, Yan Hang, , Maike Sander
The paper integrates single-cell multiomic data with genetics to identify gene regulatory changes in beta cells associated with type 2 diabetes.
bioRxiv · Dec 31, 2022 · PreprintSystems Biology