This study investigates how murine β-coronavirus infection affects oligodendrocyte survival and communication, identifying a novel ERK2 phosphorylation site on Cx47.

bioRxiv · Sep 24, 2026 · PreprintNeuroscience

CX3CR1+ microglia/macrophages, activated T cells, and IFN-γ-driven stimulation confer age-dependent protective immunity in young-adult mice following β-coronavirus infection.

Satavisha Ghosh, Bishal Hazra, Subhajit Das Sarma, Debanjana Chakravarty, Jayasri Das Sarma

This study identifies age-dependent immune mechanisms that confer neuroprotection in young-adult mice infected with β-coronavirus, highlighting differences in immune cell activation and response.

bioRxiv · Sep 18, 2026 · PreprintImmunology

CD40 Signaling Restricts Retrograde Viral Spread and Provides Neuroprotection to Retinal Ganglion Cells in a Murine β-Coronavirus Model of Optic Neuritis

Niveditha E, Bishal Hazra, Souvik Karmakar, Subhajit Das Sarma, Kenneth S. Shindler, Jayasri Das Sarma

bioRxiv · Aug 21, 2026 · PreprintImmunology

TGFb-ANGPT2-Tie2 axis in cancer-associated fibroblasts reprograms oral cancer cells to embryonic-like cell state with predictive significance of poor prognosis

Paromita Mitra, Uday Saha, Joshua Stephen Kingsly, Priyanka Prasad, Subhashree Jena, Ankit Kumar Patel, Harshavardhan BV, Santosh Kumar Mondal, Sillarine Kurkalang, Sumitava Roy, Arnab Ghosh, Shantanu Saha Roy, Jayasri Das Sarma, Nidhan K. Biswas, Moulinath Acharya, , Sandeep Singh

The paper identifies the TGFβ-ANGPT2-Tie2 axis in cancer-associated fibroblasts that reprograms oral cancer cells to an embryonic-like state, linked to poor prognosis.

Journal of Experimental & Clinical Cancer Research · May 10, 2025Peer-reviewedCancer Biology

4-Phenylbutyric acid modulates Connexin 43 expression restricting murine-β-coronavirus infectivity and virus-induced demyelination

Grishma Kasle, Madhav D. Sharma, Saurav Kumar, Pranati Das, Subhajit Das Sarma, Michael H. Koval, Anita Mahadevan, Lawrence C. Kenyon, Jayasri Das Sarma

This study shows that 4-PBA treatment reduces MHV-A59 infectivity and demyelination by preserving Cx43 and ERp29 expression in a murine model of MS.

bioRxiv · Dec 10, 2024 · PreprintNeuroscience

Ifit2 regulates murine-coronavirus spread to the spinal cord white matter and its associated myelin pathology

Madhav D. Sharma, Debanjana Chakravarty, Ajay H. Zalavadia, Amy C Burrows, Patricia A. Rayman, Nikhil Sharma, Lawrence C. Kenyon, Cornelia C. Bergmann, Ganes C. Sen, Jayasri Das Sarma

This study shows that Ifit2 deficiency in mice leads to severe viral spread and demyelination in the spinal cord during chronic RSA59 infection.

bioRxiv · Jun 6, 2022 · PreprintNeuroscience

Inducible Nitric Oxide Synthase deficiency leads to early demyelination by altering the balance between pro- and anti-inflammatory responses against Murine-β-Coronavirus

Mithila Kamble, Fareeha Saadi, Saurav Kumar, Bhaskar Saha, Jayasri Das Sarma

This study shows that iNOS deficiency in mice worsens virus-induced demyelination by altering inflammatory responses to a beta-coronavirus.

bioRxiv · Feb 8, 2022 · PreprintNeuroscience