Synthesis and characterization of chloroquine-modified albumin-binding siRNA-lipid conjugates for improved intracellular delivery and gene silencing in cancer cells
Justin Han-Je Lo, Eva F. Gbur, Nora Francini, Jinqi Ma, Alexander G. Sorets, R. Brock Fletcher, Fang Yu, Richard d’Arcy, Connor G. Oltman, Md. Jashim Uddin, Craig L. Duvall
This paper develops siRNA-CQ-L2 conjugates that enhance endosomal escape and gene silencing in cancer cells while maintaining albumin-binding properties and safety.
bioRxiv · Oct 14, 2024 · PreprintBioengineering