Nora Francini

This study evaluates how aging affects the distribution and gene silencing activity of lipid-siRNA conjugates in the cerebrospinal fluid of mice.

This paper demonstrates that an intravenous lipid-siRNA conjugate can deliver gene silencing to brain barriers without affecting parenchymal tissue.

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

This paper develops siRNA-CQ-L2 conjugates that enhance endosomal escape and gene silencing in cancer cells while maintaining albumin-binding properties and safety.

This study shows that antioxidant PPS-NPs improve porcine kidney function post-transplantation by reducing IRI through oxidative stress and inflammation mitigation.